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A high index of suspicion, early testing, and initiation of appropriate antibiotic therapy is essential. Early detection of CDI should lead to earlier treatment and earlier introduction of infection control measures. The Association for Professionals in Infection Control and Epidemiology recommends several surveillance measures (166,167): (1) a high index of suspicion in patients with risk factors for CDI (recent or current antimicrobials, use of anti-neoplastic agents, advanced age, recent hospitalization, or residence in a LTCF, previous CDI); (2) physician advocacy for the use of the best C.